| COPA DE ABIERTA DE ESTADOS UNIDOS 2022 | ||||
| 1š Ronda | ||||
| 22-mar-2022 | Berea | Clevaland SC | 2 | Derezic, Bell |
| Chicago FC United | 1 | Alami | ||
| 22-mar-2022 | Hartford | Hartford City | 0 | |
| Oyster Bay United | 3 | Rosero, Paz, Ruiz | ||
| 22-mar-2022 | Summerfield | The Villages | 6 | Rojas, Vacas (2), Farias, France, Rausch |
| Orlando FC Wolves | 0 | |||
| 22-mar-2022 | Denton | Diablos | 2 | Vargas, Cerda |
| D'Feeters Kicks | 3 | Mendez, Byass, Chavez | ||
| 22-mar-2022 | Hattiesburg | Southern States | 3 | Rivera, Shepherd (2) |
| Georgia Revolution | 1 | Tmimi | ||
| 23-mar-2022 | Los Angeles | San Fernando Valley | 6 | Bosuel (3), Rivas, Ponciano, Hermida |
| Escondido | 2 | Acha (2, 1P) | ||
| 23-mar-2022 | Columbia | South Carolina United | 1 | Robinson (P) |
| North Carolina Fusion | 3 | Hernandez-Mortimer (2), Marriott | ||
| 23-mar-2022 | Ocean City | Ocean City Nor'easters | 1(3) | Marques |
| Lansdowne Yonkers | 1(4) | Mullings | ||
| 23-mar-2022 | Hialeah | Miami United | 3 | Insua, Espindola (2) |
| City Soccer | 1 | Reyes | ||
| 23-mar-2022 | Ludlow | Western Mass Pioneers | 2 | Ganzer, Mannix |
| Brockton | 0 | |||
| 23-mar-2022 | West Des Moines | Des Moines Menace | 4 | Galizzi, Rodrigues, Salvadego (2) |
| Minneapolis City | 2 | Vang, Mesanvi | ||
| 23-mar-2022 | Tulsa | Tulsa Athletic | 3 | Ugbah, Garcia (P), Torres |
| Azteca | 0 | |||
| 24-mar-2022 | Salem | Portland Timbers III | 2 | Peterson, Sanchez |
| Contra Costa | 1 | Gonzalez | ||
| 24-mar-2022 | Las Vegas | Legends FC | 3 | Aina, Vargas, Soto |
| Park City Red Wolves | 2 | Fuchs, Jara-Collante | ||
| 30-mar-2022 | Lynchburg | Lynchburg | 1 | Reed |
| Northern Virginia | 3 | Campbell, Ayolmbong, De Souza (P) | ||
| 1-abr-2022 | Montclair | Motown | 1 | Peterson |
| West Chester United | 0 | |||
| 2š Ronda | ||||
| 5-abr-2022 | Pittsburgh | Riverhounds | 2 | Sims (2) |
| Maryland Bobcats | 0 | |||
| 5-abr-2022 | Charlotte | Independance | 2 | Dutey, Paez |
| North Carolina Fusion | 4 | Luis Neto, Joao Silva, Marriott, Lorentz | ||
| 5-abr-2022 | Hamtrack | Detroit City | 3 | Rutz, Lewis (2) |
| Michigan Stars | 0 | |||
| 5-abr-2022 | Saint Petersburg | Tampa Bay Rowdies | 6 | Mkosana (3), Scarlett, LaCava, Wyke |
| The Villages | 0 | |||
| 5-abr-2022 | Indianapolis | Indy Eleven | 0 | |
| Saint Louis City II | 2 | Armstrong, Kuzain | ||
| 5-abr-2022 | Omaha | Union | 2 | Scearce, Bertini (A) |
| Des Moines Menace | 1 | Hertzog | ||
| 5-abr-2022 | Tulsa | Tulsa | 2 | Brown, Rodriguez |
| Tulsa Athletic | 1 | Nzoijyibwami | ||
| 5-abr-2022 | San Antonio | San Antonio | 3 | Sakshaug (2), Maloney |
| D'Feeters Kicks | 1 | Mendez | ||
| 5-abr-2022 | Alburquerque | Nex Mexico United | 5 | Wehan (P), Kiesewetter (2, 1P), Ovouka, Sainte |
| Las Vegas Legends | 0 | |||
| 5-abr-2022 | Clovis | Central Valley Fuego | 4 | Bijev (2), Smith, Chaney |
| El Paso Locomotive | 1 | Calvillo | ||
| 5-abr-2022 | Irvine | Orange County | 5 | Pedersen, Iloski, Okoli, Kuningas, Henry |
| LA Force | 2 | Samuel Goņi, Torr | ||
| 6-abr-2022 | Cary | Carolina Railhawks | 1 | Servania |
| Rio Grande Valley | 2 | Lopez, Nodarse | ||
| 6-abr-2022 | Miami | Miami | 3 | Murphy (P), Reid, Parkes |
| Miami United | 0 | |||
| 6-abr-2022 | Montclair | Motown | 1 | De Oliveira |
| Syracuse Pulse | 0 | |||
| 6-abr-2022 | Louisville | Louisville City | 1 | Harris |
| Chattanooga Red Wolves | 0 | |||
| 6-abr-2022 | Ludlow | Western Mass Pioneers | 0 | |
| Flower City Union | 1 | Fernandes | ||
| 6-abr-2022 | Leesburg | Northern Virginia | 0 | |
| Richmond Kickers | 1 | Olsen | ||
| 6-abr-2022 | Madison | Forward | 3 | Sukow, Murillo, Bartman |
| Cleveland | 0 | |||
| 6-abr-2022 | Colorado Springs | Colorado Springs | 0 | |
| Northern Colorado | 1 | Desdunes | ||
| 6-abr-2022 | San Diego | ASC San Diego | 1 | Malango |
| San Diego Loyal | 2 | Conway, Crull | ||
| 6-abr-2022 | San Jose | Bay Cities | 2 | Dorwart, Cardona |
| Monterey Bay | 1 | Crawford | ||
| 6-abr-2022 | Tucson | Tucson | 3 | Crull, Romero (A), Allen |
| Las Vegas Lights | 2 | Traore, Crisostomo | ||
| 6-abr-2022 | Chandler | Phoenix Rising | 1 | Repetto |
| Valley United | 0 | |||
| 7-abr-2022 | Mount Pleasant | Charleston Battery | 0 | |
| Tormenta | 1 | Bosua | ||
| 7-abr-2022 | Rochester | New York | 1 | Rayo |
| Lansdowne Yonkers | 0 | |||
| 7-abr-2022 | Chattanooga | Chattanooga | 3 | McGrath, Ward, Gray |
| Memphis 901 | 1 | Seagrist | ||
| 7-abr-2022 | City View | Greenville Triumph | 2 | Keegan, Smart |
| Oakland Roots | 0 | |||
| 7-abr-2022 | Hartford | Hartford Athletic | 3 | Johnson, Prpa, Saydee |
| Oyster Bay United | 1 | Rosero (P) | ||
| 7-abr-2022 | Birmingham | Birmingham Legion | 3 | Kasim, Bruno Lapa, Marlon |
| Southern States | 1 | Walsh | ||
| 7-abr-2022 | Sacramento | Republic | 6 | Lacroix (2), Viader, LaGrassa, Lopez, Lewis |
| Portland Timbers III | 0 | |||
| 7-abr-2022 | Irvine | California United Strikers | 5 | Lee, Lopez-Carillo (2), Bowers, Guilherme Farias |
| San Fernando Valley | 0 | |||
| 3š Ronda | ||||
| 19-abr-2022 | Rochester | Flower City Union | 0 | |
| DC United | 3 | Kamara (2, 1P), Robertha | ||
| 19-abr-2022 | Cincinnati | Cincinnati | 2 | Barreal (2, 1P) |
| Pittsburgh Riverhounds | 0 | |||
| 19-abr-2022 | Miami | Miami FC | 0 | |
| Inter Miami | 1 | Campana | ||
| 19-abr-2022 | Hamtramck | Detroit City | 2 | Rodriguez (2, 1P) |
| Crew | 1 | Zardes (P) | ||
| 19-abr-2022 | Chicago | Fire | 2(4) | Czichos (2P) |
| Union Omaha | 2(5) | Meza, Touche | ||
| 19-abr-2022 | Birmingham | Legion | 0 | |
| Tormenta | 2 | Thorn, Dengler | ||
| 19-abr-2022 | Houston | Dynamo | 2 | Nodarse (A), Junqua |
| Rio Grande Valley | 1 | Hadebe (A) | ||
| 19-abr-2022 | Frisco | Dallas | 2 | Jara (P), Obrian |
| Tulsa | 1 | Bourgeois | ||
| 19-abr-2022 | San Jose | Earthquakes | 5 | Skahan, Marie, Cowell (P), Tsakiris, Bouda |
| Bay Cities | 0 | |||
| 19-abr-2022 | Tucson | Tucson | 1 | Calixtro |
| California Utd Strikers | 2 | Nuņo, Kawashima | ||
| 19-abr-2022 | Carson | Galaxy | 1 | Cabral |
| San Diego Loyal | 0 | |||
| 20-abr-2022 | Rochester | New York | 2(4) | Dolabella, Inalien |
| Motown | 2(3) | Daka, Fala | ||
| 20-abr-2022 | Richmond | Kickers | 1 | Terzaghi |
| North Carolina Fusion | 0 | |||
| 20-abr-2022 | Hartford | Hartford Athletic | 1 | McGlynn |
| Red Bulls | 2 | Morgan, Long | ||
| 20-abr-2022 | City View | Greenville Triumph | 1 | Keegan |
| Charlotte | 2 | Ortiz, Afful | ||
| 20-abr-2022 | Madison | Forward | 0 | |
| Minnesota United | 2 | Hunou, Kallman | ||
| 20-abr-2022 | Orlando | Orlando City | 2 | Alexandro Pato (P), Junior Urso |
| Tampa Bay Rowdies | 1 | Mkosana | ||
| 20-abr-2022 | Louisville | Louisville City | 0(9) | |
| Saint Louis City II | 0(8) | |||
| 20-abr-2022 | Kennesaw | Atlanta United | 6 | Hernandez, Dwyer (2), Moreno (P), Luiz Araujo, Lennon |
| Chattanooga | 0 | |||
| 20-abr-2022 | San Antonio | San Antonio | 2 | Collier, Manley |
| Austin | 1 | Fagundez | ||
| 20-abr-2022 | Sandy | Real Salt Lake | 0 | |
| Northern Colorado | 1 | Cornwall | ||
| 20-abr-2022 | Chandler | Phoenix Rising | 2 | Seymore (A), Hurst |
| New Mexico United | 1 | Brett | ||
| 20-abr-2022 | Sacramento | Republic | 2 | Casey, Lopez (P) |
| Central Valley Fuego | 1 | Bustamante | ||
| 20-abr-2022 | Los Angeles | Los Angeles | 5 | Musovski (2), Arango (2), Jennings |
| Orange County SC | 1 | Torres | ||
| 4š Ronda | ||||
| 10-may-2022 | Orlando | Orlando City | 2 | Kara, Perea |
| Union | 1 | Findlay | ||
| 10-may-2022 | Washington | DC United | 0 | |
| Red Bulls | 3 | Luquinhas, Tolkin, Ryan | ||
| 10-may-2022 | Hamtramck | Detroit City | 1(2) | Rodriguez (P) |
| Louisville City | 1(4) | Harris | ||
| 10-may-2022 | Fort Lauderdale | Inter | 3 | Lassiter (2), Robinson |
| Tormenta | 1 | Sterling | ||
| 10-may-2022 | Kansas City | Sporting | 4 | Vujnovic, Tzionis, Cerrillo (A), Shelton |
| Dallas | 2 | Jara, Munjoma | ||
| 10-may-2022 | Los Angeles | Los Angeles | 2 | Arango, Fall |
| Timbers | 0 | |||
| 11-may-2022 | Richmond | Richmond Kickers | 1 | Moran |
| Charlotte | 5 | Rios, Reyna, Gaines (2), Shinyashiki | ||
| 11-may-2022 | Queens | New York City | 3 | Thiago Andrade, Heber, Chanot |
| Rochester | 1 | Batiz | ||
| 11-may-2022 | Foxborough | Revolution | 5 | Gil (3, 1P), Buksa (2) |
| Cincinnati | 1 | Barreal | ||
| 11-may-2022 | Nashville | Nashville | 3 | Mukhtar (P), Sapong, Zubak |
| Atlanta United | 2 | Almada, Luiz Araujo | ||
| 11-may-2022 | Omaha | Union Omaha | 2 | Meza, Doyle |
| Northern Colorado | 0 | |||
| 11-may-2022 | Houston | Dynamo | 1 | Ferreira |
| San Antonio | 0 | |||
| 11-may-2022 | Tukwila | Sounders | 2(9) | Medranda, Montero |
| Earthquakes | 2(10) | Skahan (P), Cowell | ||
| 11-may-2022 | Sacramento | Republic | 2 | Fernandez, Martinez |
| Phoenix Rising | 0 | |||
| 11-may-2022 | Irvine | California United Strikers | 2 | Kadono, Garcia-Lopez |
| Galaxy | 3 | Joveljic (2P), Lambe | ||
| 12-may-2022 | Saint Paul | Minnesota United | 2 | Danladi, Reynoso |
| Rapids | 1 | Mezquida | ||
| Octavos de Final | ||||
| 25-may-2022 | Orlando | Orlando City | 1(4) | Torres |
| Inter | 1(2) | Mota | ||
| 25-may-2022 | Louisville | Louisville City | 1 | Ownby |
| Nashville | 2 | Loba, Mukhtar | ||
| 25-may-2022 | Queens | New York City | 1 | Rodriguez |
| Revolution | 0 | |||
| 25-may-2022 | Montclair | Red Bull | 3 | Klimala, Nealis, Barlow |
| Charlotte | 1 | Rios | ||
| 25-may-2022 | Saint Paul | Minnesota United | 1 | Hunou |
| Union Omaha | 2 | Kametani, Brito | ||
| 25-may-2022 | Kansas City | Sporting | 2 | Russell (2, 1P) |
| Dynamo | 1 | Baird | ||
| 25-may-2022 | Carson | Galaxy | 3 | Cabral, Hernandez, Joveljic |
| Los Angeles | 1 | Hollingshead | ||
| 25-may-2022 | Sacramento | Republic | 2 | Fernandes, Lopez |
| Earthquakes | 0 | Batiz | ||
| Cuartos de Final | ||||
| 21-jun-2022 | Carson | Galaxy | 1 | Donovan (A) |
| Republic | 2 | Lopez, Fernandes | ||
| 22-jun-2022 | Red Bulls | Harrison | 3 | Morgan, Luquinhas, Fernandez |
| New York City | 0 | |||
| 22-jun-2022 | Kansas City | Sporting | 6 | Salloi (2), Ford, Shelton, Hernandez (2) |
| Union Omaha | 0 | |||
| 29-jun-2022 | Orlando | Orlando | 1(6) | Schlegel |
| Nashville | 1(5) | Mukhtar | ||
| Semifinales | ||||
| 27-jul-2022 | Orlando | Orlando | 5 | Araujo (2), Pereyra, Torres, Michel |
| Red Bulls | 1 | Morgan | ||
| 27-jul-2022 | Sacramento | Republic | 0(5) | |
| Sporting | 0(4) | |||
| FINAL | ||||
| 7-sep-2022 | Orlando | Orlando | 3 | Torres (2, 1P), Michel |
| Republic | 0 | |||